This year’s agenda brings together leading researchers, clinicians, and technology developers to explore the most consequential questions facing mental health care. Through featured sessions and focused symposia, TIPS 2026 examines not only emerging discoveries—from AI chatbots and wearable sensing to multimodal biomarkers and virtual reality—but also the broader challenges of clinical translation. Together, we will critically evaluate how new tools are assessed, what it takes to deploy them equitably and responsibly, and how technological advances will reshape the future of clinical care.